Featuring articles on patisiran for transthyretin cardiac amyloidosis, automated insulin delivery in pregnancy complicated by diabetes, nemolizumab for prurigo nodularis, convalescent plasma for Covid-19–induced ARDS, and debt collection in American medicine; a case report of a man with shortness of breath; and Perspective articles on climate, health, and equity under the Farm Bill; on indigenous health perspectives on the Lāhainā fires, on whether price negotiations delay cancer-drug launches, and on the standard of care.