Featuring articles on thalidomide for recurrent bleeding due to small-intestinal angiodysplasia, pulsed field ablation for paroxysmal atrial fibrillation, perioperative chemoimmunotherapy in lung cancer, and corin and cardiac phenotypes; a review article on cystic fibrosis; a Clinical Problem-Solving on being encased in peril; and Perspective articles on minimum-staffing rules for U.S. nursing homes, on reforming pharmacy benefit managers, on scaling up point-of-care fentanyl testing, and on familiar shadows.