The ATTRibute-CM trial was a randomized, double-blind, placebo-controlled trial that evaluated the efficacy and safety of acoramidis in patients with transthyretin amyloid cardiomyopathy (ATTR-CM). The trial enrolled 632 patients with symptomatic ATTR-CM. Patients were randomly assigned to receive either acoramidis 800 mg twice daily or a placebo for 30 months.
The trial's primary endpoint was a hierarchical analysis of all-cause mortality, cardiovascular-related hospitalization, NT-proBNP, and 6-minute walk distance. The trial found that acoramidis was associated with a number of benefits compared to placebo, including:
Acoramidis was generally well-tolerated. The most common side effects were nausea, vomiting, and diarrhea.
The results of the ATTRibute-CM trial suggest that acoramidis is an effective and safe treatment for ATTR-CM. Acoramidis is a potential alternative to tafamidis, the only other FDA-approved drug tafamidis for treating ATTR-CM.
Here are some additional details about the ATTRibute-CM trial:
The results of the ATTRibute-CM trial are a major step forward in the treatment of ATTR-CM. Acoramidis offers a new option for patients with this serious condition, and it is likely to be an important treatment option for many years to come.
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