Safe, effective COVID-19 vaccines are available and increasingly accessible, but vaccine hesitancy and resistance are profound barriers to achieving effective levels of vaccination. Unless we effectively address hesitancy and resistance, we will face resurgences of the disease, causing needless suffering and death – as well as social, educational, travel, workforce productivity, and economic disruptions. Leaders of companies and organizations across the country can play an important role in encouraging vaccinations within their organizations and communities. In collaboration with Global Vaccination Advisors, the Vanguard Network will play a critical role by providing tailored communications strategies and content for leaders of companies and nonprofits.