Fibromyalgia syndrome is characterized by chronic widespread pain, multiple tender points, and often, numerous other symptoms and comorbidities including profound fatigue, and psychological symptoms. This multifaceted disorder affects many areas of an individual's life and daily function. New tools and diagnostic criteria in the updated guidelines can assist clinicians in providing optimal care to their patients with fibromyalgia, enabling clinicians to deliver the right care—at the right time—every time.