0:03

Have you ever thought about how incredibly complex

0:05

I spit is. It may only

0:07

be water, but just

0:10

aliva isn't simple. That remaining

0:12

one percent holds incredibly

0:14

meaningful information that could change

0:16

everything. And I'm not just talking about your

0:19

family treat Hi.

0:21

I'm Barret to day Thurston. And on this

0:23

season of Spit and I Heart Radio podcast

0:25

with twenty three and Me, we explore

0:27

how DNA isn't just about ancestry,

0:30

it can also be key to understanding your health.

0:36

Hello, Hello, and welcome back to

0:38

another episode of Spit.

0:41

Today we've got the one and only host

0:43

of crime Stories, Nancy Grace.

0:46

Nancy's taking a break from true crime to

0:48

get to the bottom of an entirely different

0:50

investigation her twenty three and

0:53

Me Test reports. You might know Nancy

0:55

as one of the fiercest legal analysts around,

0:57

but she's also a proud mother of twins. Well,

1:00

Nancy has covered some of the most famous and infamous

1:02

cases in American true crime. She's

1:04

also been known to share the fears and triumphs

1:06

of motherhood with her listeners. So

1:09

when Nancy and her family recently took a twenty

1:11

three me test, she just had to let

1:13

her listeners in on the journey, Nancy

1:15

sits down with a panel of experts to get a better

1:17

understanding of her family's reports and

1:20

the role genetics play in their health. And

1:22

connecting all the dots, she explores

1:24

the science behind the test and looks

1:26

to show listeners how the information

1:28

contained in twenty three and me reports can

1:31

empower you on the journey to a healthier life.

1:34

Let's listen. In twenty

1:46

three and me, you'd

1:49

have to be living under a rock

1:52

in a cave in a far

1:54

away distantly and not to know what

1:57

three and me is. It's

2:00

ancestry testing. You

2:02

find out where you're from,

2:05

who you are so to speak,

2:08

uh, chromosomely genetically

2:11

that is, can

2:14

that discovery unlock

2:17

secrets the secrets of your

2:19

genetic makeup that can help

2:21

you lead healthier

2:24

and I believe happier life. We

2:27

hear stories about genetic

2:30

tracing that you

2:33

you find distant relatives, You find

2:35

out your family tree goes all

2:38

the way back to Anglo Saxon times. But

2:40

how can it help me into here? And now I'm

2:43

raising two twins they

2:45

just turn fifteen. Let me wash my mouth

2:47

out with soap. I can't believe they're

2:50

fifteen. Can I learn

2:52

anything from this genetic

2:55

Uh? Let me say genetic

2:58

makeup, genetic identity, genetic

3:01

composite that

3:04

will help my twins and me and

3:06

my husband David and my mother Elizabeth

3:09

live a longer, healthier life.

3:12

I'mancy Grace and we are

3:14

talking about twenty three

3:16

and me with me an all star panel to

3:19

make sense of all of this. If you're a LA

3:21

person like me, I I'm just a j D. But

3:23

I know nothing about genetic

3:26

counseling. What does it mean? Joining

3:29

me up an incredible

3:31

host of yes, But I want to go first to Stacy

3:34

debt Wiler. She is

3:36

a license certified genetic counselor

3:40

with twenty three and me, Stacy,

3:43

thank you so much for being with us. Thank you here?

3:46

What is in a nutshall remember?

3:48

This is twenty three? And me for dummy's what

3:50

is twenty three? And me? Hey, guys,

3:53

by the way, I took the test, Go

3:55

ahead tell me Stacy.

3:57

It's a lot right. Um. So I think

3:59

you you kind of mentioned what people first thing about

4:01

is ancestry. But what I

4:04

really get excited about it the hall. And

4:06

there is a lot of information that you can

4:08

find out from a little bit of spit which

4:11

we're able to get DNA from, so there's

4:13

information about your own Wait, did you say

4:15

a little bit of spit? Because we have

4:17

to spit and spit and

4:20

spit. I mean I'm used to quiminal

4:22

cases, Stacy, where you get a

4:25

genetic marker and identity,

4:27

and like this is mina skill

4:29

amount of I don't

4:31

blood saliva. Why

4:34

did we have to spit so much? Yeah, that's why

4:36

we fall the spit party. Um, I

4:38

didn't think about it like that. I

4:41

don't let to Alisa take this one

4:43

a little bit, um, just because there's

4:45

you know, you need to get enough DNA from

4:47

that spit in order to be able to give

4:50

you all these insights. Um, who's over

4:52

six five? Okay,

4:54

I'll go to Alisa with me is a Lisa

4:56

Lehman, Senior manager and product science at

4:58

twenty three and me and you can

5:01

find everybody at medical dot

5:03

twenty three and me dot com

5:05

and it's and spelled out twenty

5:07

three and me dot com atly soa

5:09

welcome to you and Stacy. Why so

5:12

much spit? You know you're a pH

5:14

d and a senior manager. I feel kind

5:16

of wrong asking you why did I have

5:18

to spit so much? But why did I have to

5:20

spit so much? Oh? Thank you for having me? And why

5:23

do you have to sit so much? As the best question

5:25

I think to ask, I'd love I'd love answering

5:27

questions like this. Um. Like Stacy

5:30

said, right, what we're trying to do is get

5:32

your d NA um the easiest

5:34

way possible. Right. We don't want people to have to go give

5:36

us a blood sample, so spit very

5:38

easy to get. But what

5:40

we're doing is we're trying to get

5:42

the d N A that's in almost every cell

5:44

in your body, including the cells inside your

5:46

cheeks. So when you spit and spit and

5:49

spit, what's coming along for the ride

5:51

is some of those cheek cells um

5:53

from from your mouth. And what we're trying to

5:55

do is make sure that we're going to get enough of

5:57

those cells so we get enough DNA

6:00

to make sure that when we run and analyze

6:02

that DNA extracted from the cells,

6:04

when we try and figure out your a's

6:06

and seas and teas and gees from your

6:08

DNA, that we have enough so you don't have to do it again.

6:11

What are a's and seas and Jason T

6:13

So your DNA you can think of

6:15

as a code that

6:18

is there to um

6:21

explain how to you know what? Alsa

6:23

lame and just stop right there. My

6:26

son who is a star

6:29

in robotics and science,

6:31

and he keeps talking about coding,

6:34

and I keep acting like I know what he's talking about.

6:36

What are you talking about? So

6:39

when I'm talking about the genetic code, it

6:41

is more like you know codes during

6:43

World War Two where you are

6:45

trying there's information, but it

6:48

is written in a way that you

6:50

know you need to be able to decode it to understand

6:52

it. So your DNA is like

6:55

that. Okay, now I understand.

6:57

Now I understand with me to new

7:00

friends Stacy Entwiler and Alsa

7:02

Lehman from twenty three and me and who

7:05

longtime friends Karen Start joining

7:07

us were now psychologists joining us out

7:09

of Manhattan. You can find her at karen Start dot

7:11

com. That's Karen with a C. And Dr

7:14

Michelle dupre, my longtime

7:16

colleague joining us out of South Carolina,

7:19

forensic pathologist, medical examiner,

7:23

author of multiple books. Dr Dupree,

7:26

now, what about this a

7:29

regular role? PhD just

7:31

told me something you've never told me. I've never

7:34

heard the phrase cheek seals have you heard the

7:36

phrase cheek sales, Jackie. Yeah, you've

7:38

never mentioned that. Dupre no.

7:40

I always say epithelial sales, and

7:43

you crashed down on me for using

7:45

such a technical term. Yeah, do so.

7:48

The seals inside of your cheek are

7:51

epiphilial cells, which I always

7:53

equate with cells that come from your

7:55

skin. Well, they come from they come from the outside

7:57

of the new organ. Okay, I'm learning a lot,

8:00

you know, Karen, start joining me in New York psychologists.

8:02

Why are so many people afraid to get a

8:05

DNA test? I think they were prey nancy

8:07

to find out things that they don't know, and

8:11

the unknown can often be scary,

8:13

and especially if you get health

8:15

information and they wonder,

8:18

well, what do I do about its information

8:21

once they get it? Okay, Karen, you're so

8:23

smart. You know what? You just hit the nail on the head.

8:25

Because, um, when

8:28

we decided to do twenty three and me, I

8:30

was reading about it my daughter, this is why we did it.

8:33

My daughter wants to know her ancestry. And I

8:35

said, you're Irish, and I go to bed just

8:38

you know, I didn't know what else to say.

8:40

That's all I knew. Um, but

8:43

I knew that there was more

8:45

in the mix because my mother is

8:47

deeply all of skinned, with

8:50

black hair and amazing

8:53

blue eyes, and I

8:55

come out with, you know, really

8:57

really white and

9:00

and hazel eyes and

9:02

blonde hair, and my dad was

9:05

ready complexed. And I'm

9:07

wondering how does all this mix together when we're

9:09

basically mutts. But that

9:12

aside, Karen, start what you said.

9:15

When I started thinking about taking doing

9:17

twenty three and me and the spit party,

9:20

I think either Stacy or Elsa said spit

9:22

party. I

9:25

said, sure, I want to know all my health information.

9:28

I wan't to know everything, but when I got

9:30

the report, I had to tell you I

9:32

did have a tiny hesitation when

9:35

I clicked on UM,

9:37

I clicked on health. It's really

9:39

easy to read. Everybody, you get it

9:42

in your email or wherever you want it sent,

9:44

and don't ruin

9:47

it you for or you

9:49

Jackie, because guys,

9:52

Jackie is our executive

9:54

producer on Crime Stories. So Lucy

9:57

has always wanted her ancestry.

10:00

And I'm going to print it all out

10:02

and make it like a college diploma

10:04

looking thing and wrap it in a ribbon. And

10:07

that's going to be one of her Christmas gifts. Okay,

10:10

not from Santa, but from

10:12

me and so don't

10:14

tell or anything we're talking about,

10:17

especially you care and start. So

10:20

I was a little bit afraid when

10:22

I just a tiny bit, I had a pause.

10:25

So let me go back to you, Stacy Debt.

10:27

While are joining US Medical Affairs

10:29

Manager, what type of

10:32

health information can I learn

10:34

from twenty three and me? Yeah,

10:37

so the Helpless Ancestry Service. There's a

10:39

lot of different health replaces in there, and

10:41

the big ones that we think about are the ones that why

10:44

you information about your own

10:46

likelihood or chances for developments like

10:49

type two diabetes UM. So

10:51

this is using your own genetic information. There's

10:54

also the more general wellness

10:56

one, so big one that I think about is likelihoods

10:59

of being lack of all learning um.

11:01

But there's also reports that can provide information

11:04

about there. Do you have a theory,

11:07

a genetic theory that you might pass on your

11:09

future children that could impact them?

11:11

It helps too, So being

11:13

a genetic health I always think about the family aspect.

11:15

There's a little bit for you, there's

11:17

a little bit potentially for family members as

11:19

well. There's a lot of different information that

11:22

you can get miss um. There's even the twenty

11:24

plus membership that even opens that up more already

11:26

the additional UM insights.

11:29

So there's a lot of different health information

11:31

that you've learned about. It's not diagnostics,

11:34

but it can ultimately lead you into

11:36

the passes talking to your healthcare providers.

11:38

I mean a potential life change, diagnosis,

11:41

UM or a lot of these healthy

11:43

lifestyle is the prevention as

11:45

that can really promote these actions

11:47

that you can take every day to help

11:49

you live a longer, happier, healthy life. Well,

11:52

I gotta tell you I learned a lot. I

11:54

learned that I have a higher risk of getting

11:56

cilliac disease. Now, can somebody tell

11:58

me what that is exact? Actually? What

12:01

is that? Dr dupree Ciliac disease.

12:03

That's physically a sensitivity to gluten

12:06

which is found in flour and wheats

12:08

and things like that. Right, you're not telling me to cut

12:11

out carbs, are you? Because I don't want to hear that. I'm

12:14

not telling you. Well, I'm saying it

12:16

might be a good ideas slightly higher risk.

12:18

It is not high risk, slightly higher

12:21

exactly. And they also propensity,

12:24

It doesn't mean that it's going to happen. You had a propensity

12:26

for that also increased

12:29

likelihood of type two diabetes.

12:31

UM. Explain what

12:34

that means, Dr Dupree. But type

12:36

two diabetes UM means

12:38

that you usually acquire

12:40

diabetes later in life. UM. It

12:42

is UM. It can be controlled

12:45

by medication. It can also be controlled by nothing

12:47

more than diet and exercise. UM. If

12:49

it hasn't progressed too far, it may

12:51

require medicines such as pills, and it

12:53

may actually try into insul independence. It's

12:56

usually found in older adults. UM.

12:58

But again you're saying it can be prevented.

13:01

It can be with diet and exercise. It

13:03

can be you can actually change your

13:07

your diagnosis basically of diabetes

13:10

sometimes if it hasn't progressed your part and

13:12

if you're on a very healthy diet

13:14

and UM exercise. You know what else is

13:17

interesting? Elisa Lehman joining me senior

13:19

manager product Science at twenty three.

13:22

In me, everything was dead

13:24

on it's My

13:26

results were higher

13:28

odds of hazel eyes, which I have afraid

13:32

likely to be afraid of heights. I am not

13:34

afraid of heights. My father, however,

13:37

hated heights, hated

13:39

hyson. I will tell you after hiking

13:42

a lot Alisa all

13:45

Over that when I get

13:47

to the top of a

13:49

let's say, mountain, finally get to the top

13:52

of it. I'm not afraid

13:54

from the waist up, but from the waist

13:56

down, my legs seem

13:59

to tremble. I

14:01

can always feel it, Like when we went to

14:03

the top of a summit Grand Can and I look down.

14:06

I was talking about how beautiful it

14:08

was and trying to take pictures, but my legs

14:10

were shaking. What does that mean?

14:12

I guess that would be the fear of het Maybe a little

14:15

part of you still still care, is that? I think?

14:17

What's you know really interesting

14:19

about you know, all the information

14:21

that you can get with twenty three and me, is you see,

14:23

like how many things in your life. Jenetics

14:26

may have a little roll in, right, it may nudge

14:28

you towards one thing or another. But as you said,

14:31

it's not destiny, right, it's a it's a propensity

14:33

maybe, but you may not be afraid of heights.

14:35

Maybe you know that beautiful view overcomes

14:38

that fear for you, and you know, like you said,

14:41

legs up, you are just enjoying that

14:43

beautiful view, and a propensity for

14:45

fear of pipe doesn't matter at that point. How

14:48

in the world, though, do your chromosomes.

14:52

Um, Jackie's holding a basson. Not

14:54

afraid of hies, but am afraid of falling. Okay,

14:56

thank you, Jackie. How do

14:59

janette markers determine if you're

15:01

afraid of heights? Because my father was definitely

15:04

afraid of heights. I've never heard that

15:06

before. Anybody jump in that knows the answer

15:08

to that one, Well, I can tell you at twenty

15:10

three and me. What we do is we look

15:12

at people who tell us they're afraid of heights

15:15

and compare their DNA to

15:17

people who say they're not afraid of heights.

15:20

And what we're looking for is differences,

15:22

like different places in their d n A that's

15:24

different between those two groups. And so we

15:26

can say that people who have who are

15:29

afraid of heights tend to have this certain genetic

15:31

marker that people who aren't afraid of heights

15:33

who don't have. And then we can tell you that

15:35

that you may have this marker that seems to be associated

15:38

with being afraid of heights. You

15:53

know, really interesting thing I found

15:56

out my mom has natural degeneration

15:59

and and my mother in law, who

16:02

believe it or not, Jackie, ever since the David

16:04

and I met back in college over all

16:06

those years, I never had a single

16:08

cross word with his mother or father. Yeah,

16:12

I'm really really blessed, just just

16:15

so blessed to had them in my life.

16:18

His mother had macular degeneration

16:20

really badly. Now here's

16:22

what's interesting. I don't show a higher

16:25

likelihood of getting macular degeneration, but

16:27

my husband does. I

16:29

haven't told him yet. He's kind of like

16:32

shut down after he found out

16:34

he wasn't Scottish. Okay, so that's

16:36

a whole another thing. He is so convinced

16:38

he's Scottish. We even bought him a kilt and made

16:40

him wear at one time. Um,

16:44

he's not. He's not Scottish.

16:47

I think that he's questioning the whole

16:50

oh process because he

16:52

wants to be Scottish so badly. He loves

16:54

bagpipes, he loves everything about it. But

16:57

he found out that he's a mutt

16:59

like me and

17:00

um, and he's got a little bit of

17:02

French in German and him, and he

17:05

was just he was upset

17:07

when he found out our so called thoroughbred

17:10

dockson was part poodle. Okay.

17:12

He was very disturbed about that. So I

17:14

haven't been able to talk to him about being part

17:16

French and part German. Yet I'm

17:18

going to save it for just the right moment.

17:21

But you know, another thing I found out is

17:23

that, Um, I

17:25

knew that I was part Jewish, but

17:28

I didn't know it was Ashkenazi. Now

17:30

that is very significant because

17:32

there are certain health risks associated

17:35

with being Ashkenazi.

17:38

Does anybody know the answer to that? What are

17:40

those health risks? Yeah? I can jump in

17:42

here. Um, there's certain populations,

17:44

whether genetic variants that occur

17:47

more common, as Nazi Jewish is one

17:49

of those that we see certain genetic

17:51

condition much more common in that population.

17:54

And so one of the ones that we think

17:57

about is the r are

17:59

um inheriting breast cancer, had

18:02

a hereditary breast cancer and or variating cancer.

18:04

This frest and hold on running

18:06

that down. Hereditary breast cancer,

18:09

hereditary a varying cancer. Yes,

18:14

the rday line and r C too, and

18:17

so individuals of oh

18:19

yeah, just so you know, ladies, Karen

18:21

Stark's breast cancer survivor, go

18:25

ahead and georr you Oscanazi

18:27

Karen? So

18:31

you know we're related. Not only did

18:33

we live down the street from each other in New York, now

18:35

we find out we're related. Okay,

18:38

breast cancer, hereditary breast cancretary

18:40

of varying cancer, the brocka Chaine, and

18:42

I believe tastes lock syndrome, isn't

18:45

that. Yeah, there's a

18:48

lot of conditions that are autosomal respessive,

18:50

which is a fancy way of saying that kind of you

18:52

inherited that experience from your both

18:54

room parents, and that can result from the condition.

18:57

And we see more of the like thing

19:00

in certain populations. And

19:04

so for the r A you're talking about, that about

19:06

one in forty individuals of the Jewish

19:08

ancestry are barriers or

19:10

habits a variance that greatly increases

19:13

the risk for these certain cancers

19:15

like breasco various or costee anatic.

19:18

You know, I found out so much about my mom too,

19:21

guys. I found out that she is

19:23

partially Nigerian. I

19:25

found out so much about

19:28

mom. What what is that you care and start jeffing and

19:30

go ahead. Yeah. I wanted to say,

19:32

like, if if you get those kind

19:34

of results and they say a potensity

19:37

to a dist or something

19:39

about the brothogene, it's

19:41

really important not to be afraid,

19:43

but to go and talk to somebody

19:46

and go over it with your doctor or

19:48

a genetic counsels like you have on the show.

19:51

Hey, you know what it did to me when I

19:53

found out, um, about the

19:55

higher likelihood of getting

19:58

type two diabetes. Well, first immediately

20:00

ordered Crispy Kream's and I ate

20:02

my way through them. Then I swore

20:04

them off. I'm trying.

20:07

I have one last beender before

20:10

I went on Straight and Narrow. But

20:15

anyway back to twenty three and

20:17

me, and can we talk about

20:19

security, because um,

20:22

I found out all sorts of things in

20:25

my line of work. When you talk about d

20:27

n A tists, it's never a good thing. Okay,

20:30

you know it's as related as I'm crying. But

20:32

with twenty three and me, Um, you

20:35

can now explain this

20:37

correctly. Stacy dett

20:40

Wilder and Alisa Lehman.

20:43

You can actually have all of your your

20:45

results destroyed after

20:48

you get them. If you don't want them kept

20:50

on file, They're destroyed. They're gone, like

20:53

turning off the TV. It's over. It's

20:55

gone. Um. You can

20:57

have it not shared with the public or

21:00

shared with the public if you want. You

21:03

can have limited parts of it shared with the public

21:05

or none of it shared with the public. Is

21:07

it is all of that right? Alisa

21:10

and or Stacey. Yeah, that's

21:12

right, and I encourage everyone to

21:14

check out twenty three and me dot com slash

21:17

privacy because I think you're right

21:19

that a lot of people think about the privacy

21:21

and the security concerns about getting this

21:23

information. And we want people to

21:25

make an informed choice before they

21:28

decide to do test or not. And so we have a lot

21:30

of information about what is what

21:32

we do to protect your information. So,

21:34

yes, you can have your sample

21:37

destroyed, your DNA sample that you provide.

21:39

You can completely delete all your

21:41

information after you after you get it. You

21:43

can download all your information. You

21:45

can choose UM which reports

21:48

that you want to view or not view, and UM within

21:50

the health reports, you can choose

21:52

if you want to share information with other people

21:55

on the twenty three and me site or with

21:57

research or not UM, and

21:59

you can use what information is shared. So

22:01

you have a lot of control over

22:04

who sees your information. And we

22:06

want to make sure that people are you know, informed

22:08

of those choices ahead of time. And our

22:11

general policy is that all of these things are

22:13

opting into sharing. So

22:16

if you don't do anything, we assume you do not want

22:18

to have your information and shared. Oh

22:20

that's so smart. Guys,

22:23

what she just said. I just immediately compared

22:25

it to if you're in court and you don't

22:27

interimpl the judges automatically and there's not

22:29

guilty for you. If you don't check any

22:31

of these boxes, then they automatically

22:34

put it on privacy

22:36

where you don't share it with anyone

22:39

in any degree. And

22:41

again you can have the whole thing deleted

22:44

and your tests destroyed

22:47

if that's what you want. Hey, you know what

22:49

another thing I found out? This is so crazy,

22:51

then I am wait for it, Jackie,

22:54

wait for it. More likely

22:56

to experience here photo bleaching, which

22:59

means that when you out in the sun, your hair

23:01

turns blonder. See. I told you this was natural,

23:03

and you didn't believe me. You kept saying, who

23:06

did your hair? Or who did not do your hair? Can't

23:08

han't, can't go do your hair. See it's all

23:10

because of the sun. This is natural, right?

23:13

How do they know that? Can Alice

23:15

or Stacy tell me that that is?

23:17

That is very similar to you know, the fear

23:20

of heights, um,

23:22

you know, fear of public speaking, like preferences

23:25

like you know, whether you prefer chocolate

23:27

or vanilla ice cream? All of that is

23:29

you know, comparing the DNA as people who

23:32

who say their hair gets lighter in the sun to people

23:34

whose hair doesn't get lighter in the sun,

23:36

and finding these little places that are

23:39

are different between people who have those different experiences,

23:42

and then again being able to report

23:44

back to you based on your DNA you

23:46

might be more likely to have that

23:48

hair photo bliefing happen. Listen

23:51

to this, guys. This is what you can learn. Are

23:53

you prone to type two diabetes? If

23:56

so, what can you do about it? Im macular

23:59

degeneration? What can David and Lucy

24:01

do about it? I found out

24:03

that I was more acutely, I

24:06

have a more acute odor detection,

24:09

which is really interesting. Jackie

24:11

Karen start. Remember after COVID, both

24:13

John, David and I lost a sense of smell,

24:17

and um I first

24:19

tested about midnight. We were up watching Elf,

24:21

the Christmas movie, and um

24:24

I realized I couldn't smell Lucy's cookie shoes

24:27

making, and we went and stuck our noses

24:29

in the coffee. Couldn't smell it. We finally

24:31

the Ultimate Desk got two sharpies and stuck

24:34

them up our nostrils. Couldn't smell a

24:36

thing, And I'm like, okay, we've lost our sense of smell. Now

24:39

listen to this Karen start over.

24:42

A year later, I

24:44

think my mother smells funny. Then

24:47

I thought my friend who often

24:49

comes on our program when a rockwell smelled funny,

24:51

same smell, Jackie. Sadly, I also

24:54

thought you smelled funny. Finally,

24:56

finally I thought, how can all these

24:58

three people smell like blee? It's

25:00

me. I went to the doctor

25:03

and it was a result,

25:06

weird result of COVID having

25:08

lost my smell. And

25:10

now I find out through twenty three and me

25:13

I have increased odor detection,

25:16

more likely to match a musical pitch

25:19

boy. I wish David had gotten that one. UM

25:22

fear of high fear of public speaking.

25:25

And you learn about these things

25:27

in order to work on

25:30

them and maybe even correct

25:32

them. Um. It talks

25:34

about possibility of chronic kidney

25:37

disease, the possibility

25:39

of hyper cholesterol, and

25:42

me cholesterol, Ama, what

25:45

is that? Is that? Bad cholesterol?

25:48

What is that? Dr Dupree? Basically

25:51

hyper cholesterol a media hyper

25:53

cholesterol limia. It is actually

25:56

you have more what they call bad cholesterol

25:59

or l D all the low density, then

26:01

you do the high density, and therefore

26:03

you are more susceptible to things like stroke,

26:06

hardening of the arteries, um, even

26:08

heart attack. Well I dodged that one, so I guess it's

26:10

okay to order another round of Crispy krans

26:12

Um. Let's see. Well, I'll jump in here

26:15

shop the end our reports. Yeah,

26:17

I reports specifically on familial

26:19

hope for cholesteroling you, which is

26:21

an inherited So

26:25

why did about people have this?

26:27

And so you're typically very

26:30

early on you have very high cholesterol. So unfortunately,

26:32

most pieces of having a high cholesterol

26:35

are due to and lifestyle.

26:39

Um. So you know you can't go take

26:41

a while there. Well, so that's an X on

26:43

the own at days. That's a note

26:46

to the doughnuts legal legally

26:48

as I'm throwing you. I'm not gonna say completely

26:51

not, it's not a total note. Why

26:53

did okay, why

26:55

does John David have to take his test again?

26:58

I think did? Did? Did

27:01

he screw it up somehow? Does?

27:03

Why would he have to take his test again? Did

27:05

he not spit enough? This can happen

27:08

um so often it's because

27:10

you know, like I said, these cells in your cheeks,

27:12

that's what we're looking for, um in your

27:15

spit. So it could be that either there

27:17

weren't enough cells for whatever reason, um

27:19

that that made it into his first fit

27:21

sample. It could be that,

27:24

you know, when we when we extract the DNA out

27:26

of those cells, that we didn't get enough, or

27:29

could be that you know when we are trying to

27:31

analyze your DNA, that

27:33

there was there was an error or problem with that

27:35

analysis. But hopefully

27:38

you know, his experience was that you got a second

27:40

kid was able to give it a second try,

27:42

and we were successful that on that second on

27:44

the second try. I'm trying, but you

27:46

can't eat or drink thirty minutes before,

27:48

and it's really hard to catch John David having

27:51

not just eating something. So

27:53

I'm trying to pin him down before

27:56

he can eat or drink in

27:58

the morning to do spent Yes,

28:03

Karen Stark, Uh, he's six

28:05

five and a half and he

28:07

just turned fifteen. You know, a

28:10

feeding full of vegetables every night. Last

28:13

night he bought at Raw Carrot's. I don't

28:15

know why, but he did. But I'm working

28:17

on it. I'm working on it. Yes,

28:21

maybe guys. It's also

28:23

very easy to view online. I

28:25

don't know how it's gonna be to print it off and I make

28:28

Lucy's um Christmas scroll.

28:31

But and that's not all I'm giving her.

28:33

I'm giving her some other things too, And of course Santa's

28:35

coming. You can delete

28:37

your account, discard your sample, no one

28:40

can access your information if that's the way

28:42

you want it. I'm

28:44

really happy that I

28:47

took the test. I'm really

28:49

happy that I will be able

28:51

to answer some of Lucy's questions.

28:53

She's Brettish, she gets some Scandinavian

28:56

from her father. She gets a lot of

28:58

Irish from me. She and

29:01

I'm assuming since they're twins, John Davis,

29:03

they're both going to have osh Can Nazi jeans

29:07

within them. Of course that opens up

29:09

to a lot of health issues we're going to

29:11

look into. But now I know, and

29:13

now I can do something about

29:16

it for them. Um,

29:19

I'm just really glad it came

29:21

in into my wife. Hey,

29:23

let's let's do round robin. Final

29:26

thoughts. Dr Michelle Duffrey. I

29:28

think this is a wonderful You can

29:30

actually change your lifestyle based on

29:32

the information that you know and have a better life.

29:34

I help their life. This is great, you know,

29:36

it really is. Isn't it great to be talking

29:39

about genetic markers when it's not connected

29:41

to a crime. Okay, Karen, start and jump

29:43

in. I just think that. I mean, I

29:45

did it, and there

29:47

was nothing that was frightening.

29:50

I felt like if I needed to, I

29:52

would certainly consult you're

29:54

the doctor or a genetic council.

29:56

But there was a lot of things. There were things

29:59

I said that that we're fun, like the

30:01

chocolate or the vanilla, because my

30:03

whole family likes vanilla and

30:05

people are like, what, no chocolate?

30:07

It was really a lot of fun to get that information.

30:10

What about it? Alisa Lehman joining

30:12

me PhD seeing you manage

30:14

your products science at twenty three and me, I

30:17

mean, I think it's great to hear the

30:19

good experiences that people are having, and

30:21

it's exactly what we want, as you know, a starting

30:24

point stirt your journey, either with your ancestry

30:26

or with your health. You know, take this and

30:29

and make good choices going forward and to

30:31

Stacy while or maybe this is to at

30:33

least I'm not sure who would feel this. But we

30:36

almost didn't do it, And I'll tell you why.

30:38

When I said, hey, Twins, you want to do twenty three and me after

30:41

I told him what it was, John Davis said no, Mom,

30:43

because I don't want my great great grandson

30:46

to be busted on a felony because I

30:48

gave a DNA sample And

30:50

I almost said, where did you hear

30:52

that? And then of course I need where he heard it

30:55

from me? Okay talking about it ancestral

30:58

family trees, and I just want to point

31:00

out to Allay my

31:02

son John David's fears. Twenty three and me

31:04

has never once handed out information

31:07

to law enforcement. And

31:09

again they give you the option if you

31:11

want your test destroyed, It's

31:13

destroyed when you say do

31:15

it. Stacy Detwiler

31:18

final thoughts. You know, I think our mission

31:20

this was people to access, understand and benefit

31:22

from this information. And it's so great to hear

31:25

UM that it seems like we've done

31:27

that. We are all about the heart right.

31:30

This is your information. You have

31:32

access to learn so much from it, Um

31:35

and inspire you to make the positions that

31:37

are going to lead to that longer have to

31:39

healthier life what we want. I

31:41

just want to say thank you to twenty three and me

31:44

UM for all the questions

31:47

you've answered, and I

31:49

will let you know how Lucy response

31:52

on Christmas morning. Thanks

31:54

guys, goodbye friends, and

32:02

that's it. On another dope show.

32:05

Did this episode inspire you to take a closer

32:07

look at your health history, your genetic makeup.

32:10

Who new DNA could reveal so much about our

32:12

past while also holding the keys to certain

32:14

health insights that may impact our future.

32:17

I continue to be inspired by these stories,

32:20

and I hope you do as well. Catch

32:22

you next time. Listen

32:25

to Spit, an original podcast from

32:27

I Heart Radio and twenty three in the on

32:29

the I Heart Radio app, Apple podcast,

32:32

or wherever you get your podcast.