The Wadiyar Dynasty, also known as the Wadiyars of Mysore, is a late-medieval/early-modern South Indian Hindu royal family of the former kings of Mysore. For much of their 600 year old history, they have been trying to unsuccessfully ward off a deadly curse.

Sources: https://en.wikipedia.org/wiki/Wadiyar_dynasty, indiatvnews.com/buzz/news-mysuru-royal-baby-ends-400-year-old-curse-on-the-wodeyar-family-415914, rozbuzz.in/editors-choice/the-mysore-palace-the-queen-and-the-curse-know-the-dark-secret-of-the-mysore-royals/, qz.com/india/414978/how-a-400-year-old-curse-continues-to-haunt-one-of-indias-richest-royal-families, en.wikipedia.org/wiki/Talakadu, bangaloremirror.indiatimes.com/bangalore/others/car-pooling-uber-positive-response/articleshow/49343987.cms, ranker.com/list/famous-cursed-families-in-history/chase-christy