Featuring articles on sotorasib plus panitumumab in KRAS-mutated colorectal cancer, baricitinib and β-cells in new-onset type 1 diabetes, teplizumab in youth with new-onset type 1 diabetes, and mirvetuximab soravtansine in FRα-positive, platinum- resistant ovarian cancer; a review article on waterborne disease sensitivity to climate change; a Clinical Problem-Solving on collecting puzzle pieces; and we introduce a new series on Historical Injustices in Medicine and the Journal with our first Perspective article on Slavery and the Journal.