Featuring articles on vorasidenib for IDH-mutant low-grade glioma; a trial of dietary intervention for cognitive decline; omitting radiotherapy after breast-conserving surgery in luminal A breast cancer; gene therapy for the Crigler–Najjar syndrome; and on abortion counseling, liability, and the First Amendment; a review article on community-acquired pneumonia; a case report of a man with fever and foot pain; and Perspective articles on prioritizing mental health in the HIV/ AIDS response in Africa, on reducing health care’s climate impact, and on free and charitable clinics.