The FDA released a proposed LDT rule and stated it will “end its enforcement discretion” of LDTs. Previously, the FDA explored other avenues for regulating LDTs. We will discuss questions relevant to the draft rule and implications to laborator

MSACL 2023 : A Chat with Jennifer Van Eyk on her Distinguished Contribution Award Lecture

Apr 5th, 2023 12m 9s

Dustin Bunch chats with Jennifer Van Eyk on the fine points of her Distinguished Contribution Award lecture from the previous evening. Recorded onsite at MSACL 2023 Monterey in the Exhibit Hall.

MSACL 2023 : A Chat with Tim Collier on his Michael S Bereman Award Lecture

Apr 5th, 2023 11m 33s

Dustin Bunch chats with Tim Collier on some of the nuances of his Michael S Bereman Award for Innovative Clinical Proteomics lecture from the previous afternoon. Recorded onsite at MSACL 2023 Monterey in the Exhibit Hall.

The MetaProteomics Initiative : The Cornerstone of Comprehensive Molecular Analysis of the Microbiome Ecosystem

Mar 16th, 2023 41m 55s

Through connecting genomic and metabolic information, metaproteomics is an essential approach for understanding how microbiomes function in space and time. The international metaproteomics community is delighted to announce the launch of the Me

Paper Spray Mass Spectrometry in Clinical Application

Dec 15th, 2022 34m 31s

An interview with Lindsey Kirkpatrick, DO, PhD and Nicholas Manicke, PhD discussing the technology behind, and development of, Paper Spray technology, as well as its place in the clinical lab. Read the companion article in JMSACL, Development a

The triple quadrupole: Innovation, serendipity and persistence

Nov 2nd, 2022 42m 40s

An interview with Richard Yost, co-developer of the Triple Quadrupole Mass Spectrometer. How it was developed and why. Read the companion article in JMSACL at https://www.sciencedirect.com/science/article/pii/S2667145X22000141

JMSACL Journal Club : Supervised Machine Learning for Mass Spectrometry Data Analysis: Experts' Opinion

Mar 1st, 2022 58m 57s

We will be talking with Thomas Durant and Edward Lee about recent advances in machine learning (ML) for mass spectrometry (MS) data analysis. The primary focus will be the alignment of these two fields (ML and MS) and how this offers a promisin

Fireside Chat with Christopher Rose on Single Cell Proteomics

Sep 29th, 2021 1h 3m

Christopher Rose shares his thoughts on single cell proteomics.

JMSACL Journal Club : Understanding X-Chromosome Deletion Disorder using metabolomics and lipidomics

Aug 20th, 2021 1h 9m

X linked disorders are considerably rare and research analysing human samples is under-represented. Research undertaken in this study used neural progenitor cells from an afflicted patient to begin exploring this rare disorder. While most exper

Novel Techniques using Silicon (in silico) and Gold to Improve Imaging Results

Apr 29th, 2021 1h 1m

Untargeted small molecule machine learning for MSICameron Shedlock (until 14:00)Mass spectrometry imaging returns large dimensionally complex datasets. Traditional analysis in imaging utilizes a mindset focused on target molecule identification

JMSACL Journal Club with Benjamin Owusu

Apr 23rd, 2021 59m 21s

A presentation and discussion with Dr. Owusu on his recently published paper in JMSACL entitled Development and validation of a novel LC-MS/MS assay for C-peptide in human serum.

Electrochemical Strategies in ESI-MS for Lipid Analysis

Apr 22nd, 2021 1h 13m

Lipids play a vital role in maintaining cellular functions. Altered lipid metabolism is currently considered a hallmark of many diseases, which highlights the importance of the characterization of lipid composition in understanding, diagnosing,

Reference data-driven metabolomics and application to nutrition research

Apr 20th, 2021 1h 18m

Surveying the food-associated compounds detected in clinical samples, we can differentiate patients with specific diet types, such as predominantly animal protein- versus plant-based diet. In addition, we can identify specific foods associated

Empirically tracking the exposure of human plasma & serum samples to thawed conditions

Apr 6th, 2021 1h 16m

This presentation will described the concept, methodology, validation and performance characteristics of a 10-µL, dilute-and-shoot, intact-protein mass spectrometric assay of albumin proteoforms called “Delta-S-Cys-Albumin” that serves as an en

Getting going with MS (4) : Josh attempts method validation

Mar 9th, 2021 1h 42m

This session will outline the studies conducted and planned in order to complete validation of a mass spectrometry method in a CAP-accredited, clinical laboratory. While accuracy and precision and reportable range will be addressed, particular

Getting going with MS (3) : Josh analyzes peaks

Feb 11th, 2021 1h 37m

Unlike conventional immunoassays which provide simple (and often incorrect!) results, mass spectrometers provide a plethora of data for every peak- qualifier ions, internal standard areas, retention times, peak shapes, etc. This data, often ter

Getting going with MS (2) : Josh learns chromatography

Jan 7th, 2021 1h 37m

What do we want? Good chromatography! How do we get it? We don’t know! Columns, maybe?Good chromatography is essential to any LC-MS/MS method. Setting it up is often one of the earlier steps in developing a new method. While it can be an iterat

Vitamin D and Immune Function

Dec 8th, 2020 1h 29m

Prof. Hewison’s group is at the forefront of research linking vitamin D and the immune system, with implications for a wide range of clinical disorders including infectious, inflammatory and autoimmune disease. Current studies are focused on th

Getting going with MS (1) : Josh installs a mass spectrometer

Oct 22nd, 2020 50m 5s

This session will serve as an introduction to a 4 part series in which Dr. Hayden will invite attendees to witness in real time his journey bringing mass spec testing to a clinical lab. During these interactive sessions, attendees will be encou

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