Bryan Johnson is the world's most measured human. Johnson sold his company, Braintree Venmo, to PayPal for $800m in 2013. Through his Project Blueprint, Johnson has achieved metabolic health equal to the top 1.5% of 18 year olds, inflammation 66% lower than the average 10 year old, and reduced his speed of aging by the equivalent of 31 years.

Johnson freely shares his protocols and data publicly for everyone to use. Project Blueprint, is an endeavor to achieve humanity and earth scale cooperation starting within Self.

In 2023, Johnson launched Rejuvenation Olympics, a leaderboard assessing one's speed of aging using DNA methylation. Of the 1,750 people who have been using this state-of-the-art aging algorithm to track their progress longitudinally, Johnson ranks #1 in speed of age reduction.

Johnson is also the founder & CEO of Kernel, creator of the world’s first mainstream non-invasive neuroimaging system; and OS Fund, where he invested $100M in the predictable engineering of atoms, molecules, and organisms into companies now collectively valued over $6B. He is an outdoor adventure enthusiast, pilot, and author of children’s books, Code 7 and The Proto Project.

00:00 - Intro3:45 - Biographies5:03 - Zeroth Principles Thinking and Genius6:24 - Vision for Blueprint: A 25th Century Perspective7:50 - Blueprint, Entropy Reduction and Planet Earth9:23 - Impact of Blueprint10:47 - Gene Therapy and Breaking Through the Longevity Ceiling12:06 - Living Longer and Compounding Gains13:31 - Bryan’s Relationship With Time14:07 - Measuring Biological vs Chronological Age15:05 - Encouraging Adoption, Dashboards for Society and Learning How to Swim17:49 - Enriching vs Degrading Life and the Inevitability of Computational Intelligence21:03 - Living Forever22:19 - Knee-Jerk Reactions26:03 - Free Will28:12 - Social Drivers and Early Adopters of Blueprint30:08 - Future of Engineering Atoms, Molecules and Organisms32:43 - Critical Questions from Longer Lifespans33:58 - Kernel and the Future of Brain-Computer Interfaces36:28 - Ketamine37:47 - Storytelling, Quantifying Reality and the Extent of the Algorithm40:03 - OS Fund, Foundational Technologies and Architecting Reality43:38 - Trust and God Shaped Holes46:55 - Wealth, Effectuating Change and Competing for Legacy48:23 - What Else Would Bryan Work On?49:25 - What Should More People be Thinking About?

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