Dr. Caroline Andrew and Dr. David Nathan join the show to discuss the literature pertaining to intraoperative administration of dexamethasone. Dr. Caroline Andrew is an anesthesia resident at the Massachusetts General Hospital. Dr. David Nathan

36. Does tranexamic acid increase the risk of thromboembolism?

Dec 6th, 2023 1h

Dr. Zach Cost and Dr. Tem Bendapudi join the show to discuss the literature pertaining to tranexamic acid and thromboembolic risk. Dr. Zach Cost is an anesthesia resident at the Massachusetts General Hospital. Dr. Pavan (“Tem”) Bendapudi holds

35. Does spinal anesthesia decrease the risk of postoperative delirium?

Jul 30th, 2023 58m 7s

Dr. Mark Neuman and Dr. Sam Falkson join the show to discuss the literature around risks of regional versus general anesthesia for postoperative delirium. Dr. Neuman is the founding Director of the Center for Perioperative Outcomes Research and

34. Are double lumen endotracheal tubes superior to bronchial blockers?

Apr 2nd, 2023 46m 45s

Dr. Nick Kumar and Dr. Andy Siemens from the Massachusetts General Hospital anesthesia residency join the show to discuss the literature comparing double lumen endotracheal tubes and bronchial blockers. Dr. Dan Saddawi-Konefka joins as our facu

33. Do perioperative gabapentinoids decrease postoperative pain?

Jan 4th, 2023 27m 16s

It's our first solo episode! We review the evidence around perioperative use of gabapentinoids (gabapentin and pregabalin) and discuss interesting concepts including trial sequential analysis and minimally important difference. If you enjoy our

32: Do LMAs increase the risk of aspiration compared to ETTs? - Part II of II

Oct 18th, 2022 35m 6s

Dr. Chris Di Capua and Dr. Bryan Glezerson (@BryanGlezerson) join the show to discuss the literature around the risk of aspiration with LMAs compared to ETTs. This is an episode produced from the Depth of Anesthesia Podcast Elective that’s avai

31: Do LMAs increase the risk of aspiration compared to ETTs? - Part I of II

Aug 10th, 2022 34m 42s

Dr. Chris Di Capua and Dr. Bryan Glezerson (@BryanGlezerson) join the show to discuss the literature around the risk of aspiration with LMAs compared to ETTs. This is part I of a two-part series on LMAs. In part II, we discuss the safety of LMA

30: Live from the IARS Annual Meeting - Part II of II

May 23rd, 2022 29m 1s

In this special two-part series, we record a live episode at the International Anesthesia Research Society meeting. Dr. Dan Saddawi-Konefka and I revisit a question from our very first Depth of Anesthesia episode: is it necessary to confirm mas

29: Live from the IARS Annual Meeting - Part I of II

May 10th, 2022 30m 3s

28: What is the infectious risk of arterial catheters?

Mar 11th, 2022 32m 21s

Dr. Ben Weaver and Dr. Elisa Walsh (@elisacwalsh) from Massachusetts General Hospital join the show to discuss the literature around the infectious risk of arterial catheters and the role of barrier precautions. This is the first episode produc

27: Does BIS monitoring reduce accidental awareness during general anesthesia?

Jan 10th, 2022 44m 50s

Dr. Bryan Glezerson (@BryanGlezerson), a neuroanesthesiologist in Montreal, Canada, joins the show to discuss the literature around BIS monitoring and awareness with recall under general anesthesia. Special thanks to Dr. Ashwini Joshi for her a

26: Should buprenorphine be discontinued preoperatively?

Jul 29th, 2021 28m

Dr. Tony Anderson, an anesthesiologist at the Stanford University School of Medicine, joins us to discuss the evolving literature and evidence around perioperative management of buprenorphine. Special thanks to Dr. Ashwini Joshi for her assista

25: Should stress-dose steroids be given?

Jun 8th, 2021 38m 56s

In this episode, Dr. Jonathan Charnin and Dr. Daniel Saddawi-Konefka join us to explore the evidence around perioperative stress dose steroids and adrenal insufficiency. Thanks for listening! If you enjoy our content, leave a 5-star review on A

24: Is low flow anesthesia with sevoflurane safe?

Apr 27th, 2021 25m 38s

In this episode, Dr. Ross Kennedy and Dr. Cas Woinarski join us to discuss the evidence on whether low-flow anesthesia with sevoflurane is safe. We discuss Compound A generation and nephrotoxicity. This episode was made possible through product

23: What is the data on COVID-19 vaccines? + FAQ

Mar 30th, 2021 42m 29s

In this episode, Dr. Adam Flaczyk from Massachusetts General Hospital joins us to summarize the data on the latest COVID-19 vaccines and to answer frequently asked questions. Frequently asked questions start at 30:03 including: What is the data

22: Is evidence-based medicine easy?

Mar 16th, 2021 32m 7s

In this special episode, Dr. Justin Morgenstern of First10EM joins us to discuss a 6-step approach to primary literature. His strategy will give you the tools to feel more comfortable with taking an active role in reading and critically evaluat

21: Should smaller endotracheal tubes be used for elective surgery?

Feb 16th, 2021 38m 33s

In this episode, we explore the evidence on whether smaller endotracheal tubes are... 1. Less likely to maintain a secure patent airway 2. Less reliable in facilitating positive pressure ventilation 3. Less able to seal the trachea and protect

20: Do lower intraoperative tidal volumes reduce postoperative pulmonary complications?

Dec 11th, 2020 39m 14s

In this episode, we explore the evidence on whether lower intraoperative tidal volumes (e.g., 6 vs. 9 cc/kg) reduce postoperative pulmonary complications. Our guest is Dr. Avery Tung. Dr. Tung is Professor of Anesthesia & Critical Care at the U

19: Is hydrocortisone, ascorbic acid (Vitamin C), and thiamine therapy effective for treatment of sepsis?

Nov 11th, 2020 25m 18s

In this episode, we discuss the role of hydrocortisone, ascorbic acid (Vitamin C) and thiamine (HAT therapy) in the treatment of patients with septic shock. We discuss biological plausibility and comprehensively review the latest evidence. Our

18: Is mixing in lidocaine effective for preventing burning with propofol?

Oct 7th, 2020 28m 30s

In this episode, we discuss the mechanisms of burning with propofol infusion and explore the evidence behind strategies like mixing lidocaine with propofol. Our guest today is Dr. Stu Forman, Professor of Anesthesiology at Massachusetts General

17: Is it important to reverse to a train-of-four target of 90%? - Part 2 of 2

Sep 9th, 2020 41m 4s

In this part II or II series on neuromuscular blockade, we investigate the claim that a train-of-four target of 90% is important to achieve prior to extubation. Our guest today is Dr. Daniel Saddawi-Konefka, residency program director at Mass G

16: Is emergence from sevoflurane substantially faster than from isoflurane?

Aug 3rd, 2020 23m 12s

We investigate the claim that emergence from sevoflurane is substantially faster than from isoflurane. We explore rationales and discuss cost. Our guest today is Dr. Keith Baker, Vice Chair of Education at Massachusetts General Hospital. Conn

15: Is dural puncture epidural (DPE) the optimal labor analgesia technique?

Jul 3rd, 2020 26m 43s

In this episode, we investigate the following claims related to DPE: 1. Dural puncture epidural (DPE) technique improves analgesic quality versus traditional epidural 2. DPE technique has faster onset of analgesia versus traditional epidural 3.

14: What is the approach to post-extubation stridor in COVID-19?

May 7th, 2020 25m 41s

In this episode, we explore the evidence for various strategies to manage post-extubation stridor and the applications to COVID-19 patients. Our guest today is Dr. Tiara Calhoun (@tiaraforsyth), an internal medicine resident at the Massachusett

13: Does COVID-19 cause ARDS?

Apr 29th, 2020 40m 2s

Our guest today is Dr. Charles Hardin of the Division of Pulmonary and Critical Care Medicine at Massachusetts General Hospital. He is an active contributor to FLARE (Fast Literature Assessment and Review), a collaborative effort within the Pu