This 90-minutes symposium was presented at NACFC Anaheim 2011, offering information on the current treatment options for patients with cystic fibrosis, as well as information on emerging therapies. The topics include:- CFTR gene modifiers: what are they & how they work- The importance of the CFTR genotype/phenotype interaction- The role of gene modifiers in determining CF presentations- Using gene-targeted therapies to implement individualized treatment